The crash happened in North Amityville at about 5:50 a.m. on Thursday, Dec. 8, the Suffolk County Police Department said.
SCPD said a 51-year-old Farmingdale man was driving a 2002 Toyota Sequoia south on Route 110 when his vehicle collided with a 2004 Nissan Sentra as it crossed Route 110 from westbound Parthey Lane.
The driver of the Nissan, who hasn't been identified as of the announcement, was taken to Good Samaritan University Hospital in West Islip in critical condition, police said.
The driver of the Toyota was not injured, and his passenger suffered minor injuries in the crash, authorities said.
An investigation into the crash is ongoing.
Authorities asked anyone with information about the crash to call police at 631-854-8152.
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